The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals

Abstract Circulating phosphate levels are tightly controlled within a narrow range in mammals. By using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol hexakisphosphate kinases (IP6K) is essential for phosphate regulation in vivo. IP6K inhibition suppressed XPR1, a phosphate exporter, thereby decreasing cellular phosphate export, which resulted in increased intracellular ATP levels.

Read the source article at Nature
2021-08-11 01:00:00