Study Shows Real-World Evidence Studies Produce Similar Results to RCTs

A newly published study in JAMA finds that real-world evidence (RWE) studies produce similar results to randomized clinical trials (RCTs). The researchers analyzed 32 RCTs and created protocols for RWE studies that mirror them using the Aetion Evidence Platform (AEP). Analysis of the mirror studies showed that RWE study outcomes reached the same conclusion half of the time.

According to Aetion, “In many cases where RWE and RCTs did not come to a similar conclusion, the RCT design itself did not align with real-world clinical practice, creating a challenge for emulation of the trial using RWD. In these instances, RWE and RCTs may both be reaching meaningful conclusions, but to subtly different research questions.”

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(Source: PR Newswire, April 25^th, 2023)