Study Emulates Oncology Drug RCT Via Electronic Health Records

blue digital binary data on computer screen. Close-up shallow DOF

In a newly published study in Clinical Epidemiology, researchers were able to mirror the results of a randomized clinical trial (RCT) for a cancer drug using real-world evidence (RWE) gleaned from electronic health records (EHR). The researchers used an oncology dataset to emulate the PARSIFAL trial, which compared two drugs as adjuncts in breast cancer.

According to , “In this non-randomized study comparing the association of palbociclib and fulvestrant to palbociclib and letrozole on overall survival, we found very similar estimates and reached the same clinical conclusion as a recently completed randomized Phase 2 trial. This finding not only lends support to the utility of RWE in examining oncology treatment effectiveness but also confirms the findings of the PARSIFAL Trial.”

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(Source: Clinical Epidemiology, October 10^th, 2022)