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A real-world data study published in AIDS found that three two-drug dolutegravir combination therapies were as effective in managing HIV as commonly used three-drug treatment regimens. The study covered over 3,000 patients from 2015 and 2021 taking dolutegravir in combination with lamivudine, rilpivirine, and emtricitabine.
According to Zekerie Redzheb, “Of the people who switched to or continued on a two-drug regimen, 99% achieved or maintained viral suppression. Although representing a minor fraction of the analysed cohort, all nine previously untreated people initiating treatment on a two-drug combination also had reached viral suppression by the end of the study period.”
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(Source: AIDS Map, May 29th, 2023)