ISPOR Releases Good Practices Report on Improving Reproducibility of Real-World Evidence Studies

Although real-world evidence (RWE) studies are increasing in prominence, reproducibility issues hold back research. To address this pressing issue in the field, ISPOR has published a new paper in Value in Health describing the HARmonized Protocol Template to Enhance Reproducibility (HARPER). This framework is intended to help promote three goals the organization has established.

According to the paper, “One, to help investigators thoroughly consider, then document their choices and rationale for key study parameters that define the causal question (e.g., target estimand), two, to facilitate decision-making by enabling reviewers to readily assess potential for biases related to these choices, and three, to facilitate reproducibility.”

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(Source: Value in Health, October 2022)